Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 11/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PI4KA | P42356 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21033167 | 0.89 | PTGS1 (0.47) | EGLN1PIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL30845797 | 0.84 | TGFBR1 (0.48) | TGFBR1EGLN1NR4A2CLK1DYRK1A | |
| SCHEMBL21033568 | 0.83 | KDM4E (0.58) | EGLN1 | |
| SCHEMBL30828848 | 0.82 | PIK3CD (0.42) | TGFBR1PIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL30845756 | 0.81 | PIK3C3 (0.40) | PIK3CDPIK3CAPIK3CBPI4KAPI4KB | |
| SCHEMBL30845750 | 0.78 | KDM4E (0.38) | PIK3CDPIK3CAPIK3CBPI4KAPI4KB | |
| SCHEMBL30845778 | 0.76 | EGLN1 (0.64) | TGFBR1EGLN1CLK1DYRK1A | |
| SCHEMBL30845786 | 0.76 | EGLN1 (0.63) | TGFBR1EGLN1NR4A2 | |
| SCHEMBL29908155 | 0.75 | USP30 (0.54) | TGFBR1EGLN1CLK1 | |
| SCHEMBL30845746 | 0.74 | TGFBR1 (0.49) | TGFBR1EGLN1NR4A2CLK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | claimed |
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | disclosed |
| EP-3704120-B1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | JUBILANT EPISCRIBE LLC (US) | 2024-03-06 | — | — | EP | disclosed |