Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | TNKS | O95271 | 2/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25940751 | 0.95 | PARP1 (0.43) | PARP1TNKSTNKS2TACR1CYP11B2 | |
| SCHEMBL30136015 | 0.95 | PARP1 (0.43) | PARP1TNKSTNKS2TACR1CYP11B2 | |
| SCHEMBL31018307 | 0.95 | CYP11B2 (0.42) | PARP1TNKSTNKS2CYP11B2PRMT5 | |
| SCHEMBL25035220 | 0.95 | CYP11B2 (0.42) | PARP1TNKSTNKS2CYP11B2PRMT5 | |
| SCHEMBL26642195 | 0.93 | TLR9 (0.46) | PRMT5CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL30830495 | 0.88 | GPR119 (0.47) | CYP11B2PRMT5OPRD1OPRK1GPR119 | |
| SCHEMBL25935411 | 0.88 | PARP1 (0.43) | PARP1TNKSTNKS2TACR1CYP11B2 | |
| SCHEMBL30768744 | 0.87 | USP2 (0.50) | GPR119KITSCD5 | |
| SCHEMBL25819356 | 0.87 | CYP11B2 (0.42) | PARP1TNKSTNKS2CYP11B2PRMT5 | |
| SCHEMBL30830964 | 0.87 | GPR119 (0.44) | PARP1TNKSTNKS2TACR1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4581025-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Auron Therapeutics, Inc. (US) | 2025-07-09 | — | — | EP | disclosed |
| WO-2024050078-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AURON THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | disclosed |