Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30965537 | 0.93 | SCD5 (0.44) | HSD17B10ALDH1A1HPGDMAPK1HIF1A | |
| SCHEMBL30831067 | 0.93 | HSD17B10 (0.51) | HSD17B10ALDH1A1HPGDMAPK1HIF1A | |
| SCHEMBL30112318 | 0.91 | ALK (0.42) | HSD17B10ALDH1A1HPGDMAPK1EGLN2 | |
| SCHEMBL25034770 | 0.89 | GPR119 (0.50) | ALDH1A1GPR119CCNT1CCNA2CDK2 | |
| SCHEMBL30830960 | 0.89 | GPR119 (0.50) | ALDH1A1GPR119CCNT1CCNA2CDK2 | |
| SCHEMBL30768744 | 0.89 | USP2 (0.50) | HSD17B10ALDH1A1HPGDMAPK1HIF1A | |
| SCHEMBL31585285 | 0.86 | PARP1 (0.41) | EGLN2GPR119CCNT1CCNA2CDK2 | |
| SCHEMBL30830629 | 0.83 | CYP3A4 (0.48) | HSD17B10ALDH1A1HPGDMAPK1HIF1A | |
| SCHEMBL26641312 | 0.83 | GPR119 (0.44) | HSD17B10ALDH1A1HPGDMAPK1USP2 | |
| SCHEMBL31342432 | 0.82 | YAP1 (0.44) | GPR119PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4581025-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Auron Therapeutics, Inc. (US) | 2025-07-09 | — | — | EP | disclosed |
| WO-2024050078-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AURON THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | disclosed |