Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.38 |
| ▸ | STK10 | O94804 | 2/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR1E | P28566 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506330 | 0.78 | MAOA (0.51) | PARP1GAAKDM4EALDH1A1HPGD | |
| SCHEMBL16628857 | 0.77 | MAOA (0.41) | PARP1GAAKDM4EALDH1A1HPGD | |
| SCHEMBL9550305 | 0.77 | KCNA5 (0.40) | PARP1GAAKDM4EALDH1A1HPGD | |
| SCHEMBL262473 | 0.76 | GSK3B (0.50) | PARP1GAAKDM4EALDH1A1HPGD | |
| SCHEMBL28812042 | 0.75 | MAOA (0.59) | HPGD | |
| SCHEMBL9768590 | 0.73 | KDM4E (0.51) | PARP1GAAKDM4EALDH1A1HPGD | |
| SCHEMBL30830532 | 0.71 | DDB1 (0.64) | ALDH1A1 | |
| Water SCHEMBL8678456 | 0.71 | DDB1 (0.45) | PARP1GAAKDM4EALDH1A1HPGD | |
| SCHEMBL22904147 | 0.71 | MAOB (0.38) | CASP3 | |
| SCHEMBL8498986 | 0.70 | MAOA (0.50) | GAARXFP1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4581025-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Auron Therapeutics, Inc. (US) | 2025-07-09 | — | — | EP | disclosed |
| WO-2024050078-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AURON THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | disclosed |