Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | STK10 | O94804 | 2/20 | 0.47 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 5/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL262473 | 0.87 | GSK3B (0.50) | MAOAMAOBSTK10SLKGSK3B | |
| SCHEMBL16628857 | 0.85 | MAOA (0.41) | MAOAMAOBSTK10SLKGSK3B | |
| SCHEMBL28812042 | 0.82 | MAOA (0.59) | MAOAMAOBGSK3BKMT2AMAPT | |
| SCHEMBL2040632 | 0.82 | PARP1 (0.53) | MAOAMAOBSTK10SLKGSK3B | |
| SCHEMBL9550305 | 0.82 | KCNA5 (0.40) | MAOAMAOBSTK10SLKGSK3B | |
| SCHEMBL9768590 | 0.80 | KDM4E (0.51) | STK10SLKGSK3BKMT2ACASP3 | |
| SCHEMBL29050703 | 0.80 | MAOA (0.53) | MAOAMAOBSTK10SLKGSK3B | |
| Diphenylether SCHEMBL27584098 | 0.80 | MAOA (0.53) | MAOAMAOBSTK10SLKGSK3B | |
| SCHEMBL28099802 | 0.80 | GSK3B (0.50) | STK10SLKGSK3BKMT2APOLB | |
| SCHEMBL30830771 | 0.78 | HTR2A (0.42) | STK10SLKCASP3GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848688-A2 | INHIBITORS OF TRANSTHYRETIN AMYLOID FIBRIL FORMATION | The Scripps Research Institute (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006086517-A2 | INHIBITORS OF TRANSTHYRETIN AMYLOID FIBRIL FORMATION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-08-17 | — | — | WO | disclosed |