Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 10/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.39 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.39 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | ULK1 | O75385 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30833657 | 0.85 | ZAP70 (0.43) | IGF1RMAPK8ALKCDK19ZAP70 | |
| SCHEMBL29190671 | 0.82 | EGFR (0.49) | IGF1RALKZAP70ULK1EGFR | |
| SCHEMBL30833636 | 0.82 | ALK (0.42) | IGF1RMAPK8ALKCDK19PAK4 | |
| SCHEMBL30833634 | 0.81 | IGF1R (0.46) | IGF1RMAPK8 | |
| SCHEMBL29190628 | 0.81 | IGF1R (0.46) | IGF1RMAPK8 | |
| SCHEMBL30833790 | 0.76 | IGF1R (0.44) | IGF1RMAPK8ALKCDK19 | |
| SCHEMBL30833797 | 0.76 | ALK (0.44) | IGF1RALKEGFRJAK3 | |
| SCHEMBL30833779 | 0.76 | EGFR (0.48) | IGF1RMAPK8ALKCDK19ULK1 | |
| SCHEMBL30833709 | 0.75 | CDK1 (0.55) | IGF1RMAPK8ALKCDK19ULK1 | |
| SCHEMBL30833628 | 0.71 | IGF1R (0.46) | IGF1RMAPK8ALKCDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113896744-B | Selective EGFR inhibitor | 成都先导药物开发股份有限公司 | 2024-04-16 | — | — | CN | disclosed |