Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 4/20 | 0.53 |
| ▸ | CCNK | O75909 | 2/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | CCND3 | P30281 | 2/20 | 0.51 |
| ▸ | CDK9 | P50750 | 2/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | NEK2 | P51955 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 3/20 | 0.47 |
| ▸ | CTSC | P53634 | 1/20 | 0.46 |
| ▸ | ROS1 | P08922 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30833637 | 0.97 | MAP3K7 (0.53) | MAP3K7CCNKCCNA2CDK2CCND3 | |
| SCHEMBL30833735 | 0.88 | EGFR (0.52) | MAP3K7EGFRFLT3FGFR1SRC | |
| SCHEMBL30833720 | 0.86 | AXL (0.52) | MAP3K7CCNKCCNA2CDK2CCND3 | |
| SCHEMBL29190531 | 0.84 | ALK (0.65) | MAP3K7CCNKCCNA2CDK2CCND3 | |
| SCHEMBL30833713 | 0.83 | AXL (0.52) | MAP3K7CCNKCCNA2CDK2CCND3 | |
| SCHEMBL29190637 | 0.81 | ALK (0.65) | MAP3K7CCNKCCNA2CDK2CCND3 | |
| SCHEMBL16966032 | 0.78 | INSR (0.53) | MAP3K7CCNKCCNA2CDK2CCND3 | |
| SCHEMBL26611961 | 0.78 | EGFR (0.72) | MAP3K7EGFRALKFLT3FGFR1 | |
| SCHEMBL30833783 | 0.78 | SYK (0.47) | MAP3K7CCNKCCNA2CDK2CCND3 | |
| SCHEMBL16966205 | 0.77 | MET (0.47) | MAP3K7CCNKCCNA2CDK2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113896744-B | Selective EGFR inhibitor | 成都先导药物开发股份有限公司 | 2024-04-16 | — | — | CN | disclosed |