Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21014266 | 0.88 | PLK1 (0.47) | PLK1EGLN1CA12CA1CA2 | |
| SCHEMBL21001692 | 0.84 | KDM4E (0.54) | PLK1EGLN1LMNATSHRNFKB1 | |
| SCHEMBL30845769 | 0.84 | TGFBR1 (0.46) | TGFBR1EGLN1HTT | |
| SCHEMBL29382012 | 0.82 | HDAC6 (0.50) | TGFBR1EGLN1 | |
| SCHEMBL30845747 | 0.82 | SMN1; SMN2 (0.50) | TGFBR1EGLN1LMNATSHRRAB9A | |
| SCHEMBL30845795 | 0.79 | TGFBR1 (0.48) | TGFBR1EGLN1 | |
| SCHEMBL8065354 | 0.76 | TGFBR1 (0.50) | TGFBR1EGLN1LMNATSHRRAB9A | |
| SCHEMBL30845768 | 0.75 | TGFBR1 (0.54) | TGFBR1EGLN1NR4A2 | |
| SCHEMBL5843831 | 0.74 | PLK1 (0.67) | PLK1CA12CA1CA2CA9 | |
| SCHEMBL30845779 | 0.74 | TGFBR1 (0.58) | TGFBR1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | claimed |
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | disclosed |