Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13144705 | 0.83 | OPRM1 (0.45) | OPRM1OPRD1SLC6A2OPRK1ACHE | |
| SCHEMBL12369440 | 0.83 | OPRM1 (0.45) | OPRM1OPRD1SLC6A4SLC6A2OPRK1 | |
| SCHEMBL8959998 | 0.83 | SLC6A3 (0.42) | OPRM1OPRD1SLC6A4SLC6A2OPRK1 | |
| Hydrochloric Acid SCHEMBL9311016 | 0.81 | OPRM1 (0.44) | OPRM1OPRD1SLC6A4SLC6A2OPRK1 | |
| Hydrochloric Acid SCHEMBL9310877 | 0.81 | OPRM1 (0.44) | OPRM1OPRD1SLC6A4SLC6A2OPRK1 | |
| Hydrochloric Acid SCHEMBL9311181 | 0.81 | SLC6A3 (0.41) | OPRM1OPRD1SLC6A4SLC6A2OPRK1 | |
| SCHEMBL1764933 | 0.81 | HTR2A (0.50) | OPRM1OPRD1SLC6A4OPRK1CYP2D6 | |
| SCHEMBL15093618 | 0.81 | HTR2A (0.50) | OPRM1OPRD1SLC6A4OPRK1CYP2D6 | |
| SCHEMBL15093858 | 0.81 | HTR2A (0.50) | OPRM1OPRD1SLC6A4OPRK1CYP2D6 | |
| Hydrochloric Acid SCHEMBL10754178 | 0.80 | HTR2A (0.48) | OPRM1OPRD1OPRK1CYP2D6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790898-B2 | Substituted 3-phenylpiperidine compounds, their preparation and use | GRUENENTHAL GMBH (DE) | 2010-09-07 | — | — | US | disclosed |
| US-20070173533-A1 | Substituted 3-phenylpiperidine compounds, their preparation and use | GRUENENTHAL GMBH (DE) | 2007-07-26 | — | — | US | disclosed |
| EP-1771417-A1 | SUBSTITUTED 3-PHENYLPIPERIDINE DERIVATIVES | Grünenthal GmbH (DE) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006010577-A1 | SUBSTITUTED 3-PHENYLPIPERIDINE DERIVATIVES | Grünenthal GmbH (DE) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173533-A1 | Substituted 3-phenylpiperidine compounds, their preparation and use | OPRK1, OPRD1, OPRL1 | OPRM1 4/4885OPRD1 2/4885SLC6A4 978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.