Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | HTR3A | P46098 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.36 |
| ▸ | NCF1 | P14598 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30847664 | 0.80 | MAPT (0.39) | ADRB1ALDH1A1MAPTTHRBL3MBTL1 | |
| SCHEMBL30847592 | 0.72 | CMA1 (0.34) | ADRB1MAPTCACNA1HCYP1A2CYP2C19 | |
| SCHEMBL19403771 | 0.69 | ADRB2 (0.56) | ADRB1HTR3AHTR2CHTR3EHTR3B | |
| SCHEMBL391593 | 0.69 | CES2 (0.45) | ALDH1A1SMN1; SMN2CACNA1H | |
| Hydrochloric Acid SCHEMBL19385636 | 0.68 | MAPT (0.56) | ADRB1HTR3AHTR2CHTR3EHTR3B | |
| SCHEMBL7559328 | 0.68 | ADRB2 (0.55) | ADRB1HTR3AHTR2CHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL4424049 | 0.68 | MAPT (0.56) | ADRB1HTR3AHTR2CHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL7554207 | 0.67 | MAPT (0.55) | ADRB1HTR3AHTR2CHTR3EHTR3B | |
| SCHEMBL1914919 | 0.65 | ADRB1 (1.00) | ADRB1HTR3AHTR2CHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL30955834 | 0.64 | ADRB1 (0.96) | ADRB1HTR3AHTR2CHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598901-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | Thomas Jefferson University (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076964-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-04-11 | — | — | WO | disclosed |