Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.36 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.36 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30847652 | 0.80 | ADRB1 (0.47) | MAPTTHRBL3MBTL1ADRB1ALDH1A1 | |
| SCHEMBL18593377 | 0.76 | ALDH1A1 (0.45) | MAPTHPGDKDM4ELMNAGAA | |
| SCHEMBL18593375 | 0.75 | ALDH1A1 (0.47) | MAPTHPGDKDM4ELMNAGAA | |
| SCHEMBL391593 | 0.74 | CES2 (0.45) | NOTUMALDH1A1 | |
| SCHEMBL30847592 | 0.72 | CMA1 (0.34) | MAPTMEN1KMT2AADRB1TSHR | |
| SCHEMBL10104536 | 0.71 | MAPT (0.40) | MAPTKDM4ELMNAKDRSRPK2 | |
| SCHEMBL10104521 | 0.70 | MAPT (0.40) | MAPTHPGDLMNAKDRSRPK2 | |
| SCHEMBL3849954 | 0.69 | NOTUM (0.54) | NOTUM | |
| SCHEMBL29118478 | 0.69 | ALDH1A1 (0.40) | MAPTKDM4ELMNANOTUMMEN1 | |
| SCHEMBL5517347 | 0.69 | CES2 (0.41) | KDM4EMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598901-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | Thomas Jefferson University (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076964-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-04-11 | — | — | WO | disclosed |