Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 7/20 | 0.36 |
| ▸ | LIPE | Q05469 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30847685 | 0.82 | MEN1 (0.35) | MEN1KMT2ADRD2DRD3ALDH1A1 | |
| SCHEMBL30847713 | 0.80 | POLQ (0.41) | POLQDRD2DRD3KCNH2TACR1 | |
| SCHEMBL30847735 | 0.80 | POLQ (0.38) | POLQDRD2DRD3TACR1 | |
| SCHEMBL30847729 | 0.80 | POLQ (0.38) | POLQDRD2DRD3TACR1 | |
| SCHEMBL30847656 | 0.79 | DRD2 (0.34) | DRD2DRD3KCNH2SCN9ASCN10A | |
| SCHEMBL30847546 | 0.79 | POLQ (0.37) | POLQ | |
| SCHEMBL30847772 | 0.78 | POLQ (0.38) | POLQDRD2DRD3KCNH2SCN9A | |
| SCHEMBL30847683 | 0.76 | POLQ (0.38) | POLQTACR1 | |
| SCHEMBL30847786 | 0.75 | POLQ (0.39) | POLQNPSR1SCN9ATACR1 | |
| SCHEMBL30847774 | 0.75 | POLQ (0.41) | POLQLIPETACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598901-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | Thomas Jefferson University (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076964-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-04-11 | — | — | WO | disclosed |