Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | DRD3 | P35462 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | RXRB | P28702 | 2/20 | 0.35 |
| ▸ | RXRG | P48443 | 2/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30847685 | 0.84 | MEN1 (0.35) | DRD2DRD3KCNH2TACR1AR | |
| SCHEMBL30847704 | 0.84 | AR (0.36) | DRD2DRD3KCNH2TACR1AR | |
| SCHEMBL30847744 | 0.84 | AR (0.36) | DRD2DRD3KCNH2TACR1AR | |
| SCHEMBL30847657 | 0.79 | SCN5A (0.43) | TACR1PTPN2PTPN1PTPN6RXRA | |
| SCHEMBL30847650 | 0.79 | ALOX5 (0.39) | TACR1ARPTPN2PTPN1PTPN6 | |
| SCHEMBL30847611 | 0.78 | DRD3 (0.40) | DRD2DRD3KCNH2MEN1KMT2A | |
| SCHEMBL30847795 | 0.75 | CYP1A2 (0.41) | TACR1PTPN2PTPN1PTPN6RXRA | |
| SCHEMBL30847713 | 0.73 | POLQ (0.41) | DRD2DRD3KCNH2TACR1 | |
| SCHEMBL30847678 | 0.73 | POLQ (0.43) | DRD2DRD3KCNH2 | |
| SCHEMBL29317047 | 0.70 | HTT (0.44) | ARPTPN2PTPN1PTPN6RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598901-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | Thomas Jefferson University (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076964-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-04-11 | — | — | WO | disclosed |