Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 5/20 | 0.42 |
| ▸ | YAP1 | P46937 | 3/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | F13A1 | P00488 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | TGM1 | P22735 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 3/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30847726 | 0.79 | DRD2 (0.38) | SCN9ATACR1PTPN2PTPN1PTPN6 | |
| SCHEMBL30847580 | 0.79 | SCN5A (0.43) | SCN5ASCN9ATACR1CETPTHRB | |
| SCHEMBL29317051 | 0.78 | PPARG (0.41) | TACR1PTPN2PTPN1PTPN6 | |
| SCHEMBL29317040 | 0.78 | TACR1 (0.40) | TACR1YAP1CASP1CETPPTPN2 | |
| SCHEMBL30847650 | 0.76 | ALOX5 (0.39) | TACR1PTPN2PTPN1PTPN6RXRA | |
| SCHEMBL30847685 | 0.76 | MEN1 (0.35) | SCN9ATACR1 | |
| SCHEMBL30847744 | 0.75 | AR (0.36) | SCN9ATACR1PTPN2PTPN1PTPN6 | |
| SCHEMBL30847704 | 0.75 | AR (0.36) | SCN9ATACR1PTPN2PTPN1PTPN6 | |
| SCHEMBL30847795 | 0.75 | CYP1A2 (0.41) | TACR1PTPN2PTPN1PTPN6RXRA | |
| SCHEMBL14019898 | 0.69 | NPC1 (0.51) | SCN5ASCN9AHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598901-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | Thomas Jefferson University (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076964-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-04-11 | — | — | WO | disclosed |