Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27137524 | 1.00 | RXRA (0.49) | RXRAGRIN1GRIN2BCYP3A4CYP2C19 | |
| SCHEMBL27137528 | 0.78 | PKM (0.40) | RXRAGRIN1GRIN2BMAPTPKM | |
| SCHEMBL15454013 | 0.74 | LOXL2 (0.46) | CYP3A4MAPTPKMPTGS2ALOX15B | |
| SCHEMBL30016369 | 0.74 | LOXL2 (0.46) | CYP3A4MAPTPKMPTGS2ALOX15B | |
| SCHEMBL19211469 | 0.72 | NOTUM (0.63) | RXRAGRIN1GRIN2BL3MBTL1NOTUM | |
| SCHEMBL15454141 | 0.68 | MAPT (0.61) | MAPTPKMPTGS2ALOX15BL3MBTL1 | |
| SCHEMBL21614668 | 0.68 | CYP3A4 (0.67) | RXRAGRIN1GRIN2BCYP3A4CYP2C19 | |
| SCHEMBL31755983 | 0.68 | RXRA (0.48) | RXRAGRIN1GRIN2BNOTUM | |
| SCHEMBL27137532 | 0.68 | RXRA (0.48) | RXRAGRIN1GRIN2BCYP3A4CYP2C19 | |
| SCHEMBL21614685 | 0.67 | NOTUM (0.51) | RXRAGRIN1GRIN2BCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4577536-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | Hotspot Therapeutics, Inc. (US) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024044730-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |