SCHEMBL28657494

SCHEMBL28657494

Nc1cc(N)c2c(-c3ccccc3)c(-c3ccccc3)[nH]c2c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 4/20 0.49
ESR2 Q92731 4/20 0.49
EGFR P00533 1/20 0.41
PTGS2 P35354 6/20 0.40
CHEK1 O14757 3/20 0.39
CDK1 P06493 3/20 0.39
MAPK1 P28482 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
RPS6KA3 P51812 1/20 0.38
KDM4E B2RXH2 3/20 0.37
MAPT P10636 3/20 0.37
ALDH1A1 P00352 2/20 0.37
GFER P55789 2/20 0.37
NPC1 O15118 1/20 0.37
GLA P06280 1/20 0.37
GAA P10253 1/20 0.37
HPGD P15428 1/20 0.37
HTT P42858 1/20 0.37
RAB9A P51151 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3085172 0.80 ESR1 (0.49) ESR1ESR2EGFRPTGS2CHEK1
SCHEMBL3881310 0.72 CDK4 (0.51) EGFRKDM4EMAPTALDH1A1GLA
SCHEMBL28153334 0.71 MAOA (0.48) MAPK1NPSR1KDM4EMAPTALDH1A1
SCHEMBL1934974 0.70 ESR1 (0.53) ESR1ESR2PTGS2CHEK1CDK1
SCHEMBL3884388 0.69 TYMS (0.35) ALDH1A1
SCHEMBL9775858 0.69 HSD17B10 (0.58) ESR1ESR2PTGS2MAPK1NPSR1
SCHEMBL21310428 0.69 HSD17B10 (0.58) ESR1ESR2PTGS2MAPK1NPSR1
SCHEMBL18610257 0.69 ESR1 (0.73) ESR1ESR2EGFRPTGS2KDM4E
SCHEMBL24254914 0.68 HSD17B10 (0.56) MAPK1KDM4EMAPTALDH1A1NPC1
SCHEMBL18552201 0.67 ESR1 (0.69) ESR1ESR2PTGS2NPC1MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113577027-A Reinforced preparation method of polymer-stabilized inorganic antibacterial nanoparticles 华东理工大学 2021-11-02 CN disclosed