Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3081032 | 0.87 | CYP3A4 (0.56) | ALDH1A1CYP1A2LMNA | |
| SCHEMBL3091158 | 0.86 | ALDH1A1 (0.52) | ALDH1A1CYP1A2LMNAPKMOPRM1 | |
| SCHEMBL3079273 | 0.85 | ALDH1A1 (0.51) | ALDH1A1CYP1A2LMNAPKMOPRM1 | |
| SCHEMBL3086931 | 0.84 | ALDH1A1 (0.55) | ALDH1A1CYP1A2LMNAPKM | |
| SCHEMBL3083741 | 0.84 | ALDH1A1 (0.50) | ALDH1A1CYP1A2LMNAPKMOPRM1 | |
| SCHEMBL3075559 | 0.84 | ALDH1A1 (0.50) | ALDH1A1CYP1A2LMNAPKMOPRM1 | |
| SCHEMBL3080049 | 0.84 | PROKR1 (0.53) | ALDH1A1CYP1A2LMNAPKM | |
| SCHEMBL3081026 | 0.84 | LMNA (0.53) | ALDH1A1L3MBTL1CYP1A2LMNAPKM | |
| SCHEMBL3087858 | 0.84 | CYP3A4 (0.55) | ALDH1A1CYP1A2 | |
| SCHEMBL3086922 | 0.83 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1CYP1A2LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790898-B2 | Substituted 3-phenylpiperidine compounds, their preparation and use | GRUENENTHAL GMBH (DE) | 2010-09-07 | — | — | US | claimed |
| US-20070173533-A1 | Substituted 3-phenylpiperidine compounds, their preparation and use | GRUENENTHAL GMBH (DE) | 2007-07-26 | — | — | US | claimed |
| US-7790898-B2 | Substituted 3-phenylpiperidine compounds, their preparation and use | GRUENENTHAL GMBH (DE) | 2010-09-07 | — | — | US | disclosed |
| US-20070173533-A1 | Substituted 3-phenylpiperidine compounds, their preparation and use | GRUENENTHAL GMBH (DE) | 2007-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173533-A1 | Substituted 3-phenylpiperidine compounds, their preparation and use | OPRK1, OPRD1, OPRL1 | ALDH1A1 698/4885L3MBTL1 3501/4885CYP1A2 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.