Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | LPL | P06858 | 3/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | LIPE | Q05469 | 2/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.30 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1484864 | 0.80 | APLNR (0.38) | EGFRALPLLPLLIPGBTK | |
| SCHEMBL30292561 | 0.80 | APLNR (0.38) | EGFRALPLLPLLIPGBTK | |
| SCHEMBL15995921 | 0.79 | NOS3 (0.39) | EGFRLPLLIPGJAK2BTK | |
| SCHEMBL13527502 | 0.79 | LPL (0.44) | LPLLIPGJAK2BTK | |
| Water SCHEMBL2513501 | 0.79 | APLNR (0.37) | EGFRALPLLPLLIPGBTK | |
| SCHEMBL5784094 | 0.77 | IDO1 (0.41) | EGFRALDH1A1LPLLIPGJAK2 | |
| SCHEMBL14564295 | 0.77 | EGFR (0.34) | EGFRALDH1A1CYP1A2LPLLIPG | |
| SCHEMBL32691484 | 0.76 | KDM4E (0.39) | ALDH1A1LPLLIPGJAK2BTK | |
| SCHEMBL27403756 | 0.76 | UCHL1 (0.34) | EGFRALPLLPLLIPGJAK2 | |
| SCHEMBL20954109 | 0.75 | EGFR (0.36) | EGFRALPLLPLLIPGLIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059559-A1 | ISOTHIAZOLYLCARBOXAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-03-21 | — | — | WO | disclosed |