SCHEMBL308538

SCHEMBL308538

Brc1ccnc(-c2ccccn2)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.61
LMNA P02545 3/20 0.61
CCR1 P32246 3/20 0.61
CCR5 P51681 3/20 0.61
CCR8 P51685 3/20 0.61
CYP1A2 P05177 1/20 0.61
POLB P06746 1/20 0.61
METAP1 P53582 1/20 0.61
BLM P54132 1/20 0.61
HIF1A Q16665 1/20 0.61
DOHH Q9BU89 1/20 0.61
P4HTM Q9NXG6 1/20 0.61
NPC1 O15118 5/20 0.52
RAB9A P51151 4/20 0.52
TP53 P04637 3/20 0.52
ALOX15 P16050 2/20 0.52
HTT P42858 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
L3MBTL1 Q9Y468 2/20 0.52
TDP1 Q9NUW8 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8814176 0.92 KDM4E (0.67) KDM4ELMNACCR1CCR5CCR8
SCHEMBL833371 0.86 KDM4E (0.48) KDM4ELMNACCR1CCR5CCR8
SCHEMBL30362730 0.84 KDM4E (0.46) KDM4ELMNACCR1CCR5CCR8
SCHEMBL2138914 0.83 CCR1 (0.64) KDM4ELMNACCR1CCR5CCR8
SCHEMBL30046929 0.83 CCR1 (0.64) KDM4ELMNACCR1CCR5CCR8
SCHEMBL12893405 0.83 CCR1 (0.52) KDM4ELMNACCR1CCR5CCR8
SCHEMBL4803 0.78 ASIC3 (0.59) KDM4ELMNANPC1RAB9ASMN1; SMN2
Dipyridyl SCHEMBL7732129 0.78 KDM4E (0.88) KDM4ELMNACCR1CCR5CCR8
Dipyridyl SCHEMBL9299834 0.78 KDM4E (0.88) KDM4ELMNACCR1CCR5CCR8
SCHEMBL1181563 0.78 KDM4E (0.88) KDM4ELMNACCR1CCR5CCR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025132825-A1 1H-IMIDAZO[4,5-C]QUINOLINE METAL-BASED COMPLEXES USEFUL AS MEDICAMENTS FUNDACIÓN DONOSTIA INTERNATIONAL PHYSICS CENTER - DIPC (ES) 2025-06-26 WO claimed
CN-118184709-A Iridium (III) complex with low-voltage phosphorescence switch response, and preparation and application thereof 南京邮电大学 2024-06-14 CN claimed
CN-113663733-B Preparation and application of graphene covalent supported bipyridine metal complex catalyst 合肥工业大学 2023-06-06 CN claimed
US-20230167144-A1 PREPARATION AND ITS APPLICATION OF A CYANIDE-BRIDGED METAL ORGANIC COMPOUND WITH INTRAMOLECULAR MAGNETIC TRANSFORMATION Hubei Jingmen Industrial Technology Research Institute Co., Ltd. (CN) 2023-06-01 US claimed
CN-115093572-B Polypyridine ring metal iridium supermolecular material, preparation method and application 广州大学 2023-05-26 CN claimed
CN-115819472-A Polypyridine metal complex and preparation method thereof 广州大学 2023-03-21 CN claimed
CN-115093572-A Polypyridine ring metal iridium supramolecular material, preparation method and application 广州大学 2022-09-23 CN claimed
CN-113663733-A Preparation and application of graphene covalent load bipyridine metal complex catalyst 合肥工业大学 2021-11-19 CN claimed
CN-111518145-A Cyanide-bridged metal organic compound with intramolecular magnetic transformation, and preparation method and application thereof 荆楚理工学院 2020-08-11 CN claimed
US-20260053393-A1 NEAR-IR GLUCOSE SENSORS PROFUSA INC (US) 2026-02-26 US disclosed
US-20250230174-A1 NEAR-IR GLUCOSE SENSORS PROFUSA, INC. (US) 2025-07-17 US disclosed
WO-2025132825-A1 1H-IMIDAZO[4,5-C]QUINOLINE METAL-BASED COMPLEXES USEFUL AS MEDICAMENTS FUNDACIÓN DONOSTIA INTERNATIONAL PHYSICS CENTER - DIPC (ES) 2025-06-26 WO disclosed
US-20250172566-A1 SACCHARIDE SENSING SYSTEMS Carbometrics Limited (GB) 2025-05-29 US disclosed
US-12285250-B2 Near-IR glucose sensors PROFUSA, INC (US) 2025-04-29 US disclosed
EP-1230248-A2 TRANSITION METAL COMPLEXES ATTACHED TO A POLYMER VIA A FLEXIBLE CHAIN Therasense, Inc. (US) 2002-08-14 EP disclosed
WO-2001036660-A2 TRANSITION METAL COMPLEXES ATTACHED TO A POLYMER VIA A FLEXIBLE CHAIN THERASENSE, INC. (US) 2001-05-25 WO disclosed
US-6187928-B1 TREATING FUNGAL DISEASES THE ROCKEFELLER UNIVERSITY 2001-02-13 US disclosed
US-6087510-A Method of use of imidazolium cations THE ROCKEFELLER UNIVERSITY (US) 2000-07-11 US disclosed
US-5969150-A FLUORESCENT COMPOUNDS FOR MEDICAL DIAGNOSIS, DRUGS AND LABELS OR FUNGICIDES AND VIRICIDES THE ROCKEFELLER UNIVERSITY (US) 1999-10-19 US disclosed
US-5874587-A FLUORESCENCE THE ROCKEFELLER UNIVERSITY (US) 1999-02-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250230174-A1 NEAR-IR GLUCOSE SENSORS IRS1, INSR, SLC2A4 KDM4E 3160/4885LMNA 4310/4885CCR1 4198/4885
US-20260053393-A1 NEAR-IR GLUCOSE SENSORS INSR, IRS1, SLC2A4 KDM4E 3774/4885LMNA 1439/4885CCR1 154/4885
US-20250172566-A1 SACCHARIDE SENSING SYSTEMS GALE, SLC2A8, SLC2A4 KDM4E 3362/4885LMNA 4421/4885CCR1 1640/4885
US-12285250-B2 Near-IR glucose sensors IRS1, SLC2A4, GPR119 KDM4E 1818/4885LMNA 4186/4885CCR1 3613/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.