Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Metaxon. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metaxon SCHEMBL5475058 | 0.97 | CYP1A2 (0.61) | CYP1A2CYP2C9HIF1ALMNASMN1; SMN2 | |
| Metaxon SCHEMBL1895014 | 0.97 | CYP1A2 (0.61) | CYP1A2CYP2C9HIF1ALMNASMN1; SMN2 | |
| Metaxon SCHEMBL18221953 | 0.97 | CYP1A2 (0.61) | CYP1A2CYP2C9HIF1ALMNASMN1; SMN2 | |
| SCHEMBL30898299 | 0.84 | PTGDR2 (0.59) | CYP1A2CYP2C9HIF1ALMNASMN1; SMN2 | |
| SCHEMBL8605798 | 0.83 | CYP1A2 (0.64) | CYP1A2CYP2C9HIF1ALMNASMN1; SMN2 | |
| Metaxon SCHEMBL117877 | 0.83 | TDP1 (0.70) | CYP1A2CYP2C9HIF1ALMNASMN1; SMN2 | |
| 2,4-Dichlorophenoxyacetic Acid SCHEMBL13571537 | 0.83 | TDP1 (0.70) | LMNASMN1; SMN2HPGDTSHRMEN1 | |
| SCHEMBL1195318 | 0.83 | CYP1A2 (0.64) | CYP1A2CYP2C9HIF1ALMNASMN1; SMN2 | |
| SCHEMBL11640730 | 0.83 | CYP1A2 (0.64) | CYP1A2CYP2C9HIF1ALMNASMN1; SMN2 | |
| Metaxon SCHEMBL28947787 | 0.83 | TDP1 (0.60) | CYP1A2CYP2C9HIF1ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118057522-A | Speech synthesis method, model training method, device, equipment and storage medium | 科大讯飞股份有限公司 | 2024-05-21 | — | — | CN | disclosed |