Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.32 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.32 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30867870 | 0.89 | NR1H2 (0.34) | HDAC1PIK3CAMTORPIK3CGATR | |
| SCHEMBL30867869 | 0.89 | HDAC1 (0.34) | HDAC1NR1H2NR1H3 | |
| SCHEMBL30867686 | 0.85 | HSD11B1 (0.35) | HDAC1 | |
| SCHEMBL30911096 | 0.82 | SMARCA2 (0.48) | PIK3CAMTORPIK3CGATRAURKB | |
| SCHEMBL30867805 | 0.81 | NR1H2 (0.33) | HDAC1ARUSP30NR1H2NR1H3 | |
| SCHEMBL38653820 | 0.73 | ACACB (0.36) | — | |
| SCHEMBL30867765 | 0.70 | GPR119 (0.51) | PIK3CAPIK3R1SMARCA2SMARCA4PBRM1 | |
| SCHEMBL30911167 | 0.70 | GPR119 (0.46) | PIK3CAPIK3R1USP30SMARCA2SMARCA4 | |
| SCHEMBL30911135 | 0.70 | GPR119 (0.46) | PIK3CAPIK3R1USP30SMARCA2SMARCA4 | |
| SCHEMBL38654099 | 0.69 | GPR119 (0.46) | PIK3CAPIK3R1USP30SMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598917-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076674-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |