Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 5/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.33 |
| ▸ | CDK9 | P50750 | 5/20 | 0.33 |
| ▸ | FYN | P06241 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30867708 | 0.85 | PLG (0.32) | — | |
| SCHEMBL30867883 | 0.84 | TLR8 (0.33) | TLR8TLR7 | |
| SCHEMBL38654423 | 0.83 | HTR2A (0.31) | HTR2C | |
| SCHEMBL30867858 | 0.83 | HTR2A (0.31) | HTR2C | |
| Hydrochloric Acid SCHEMBL30867700 | 0.76 | — | — | |
| SCHEMBL38653881 | 0.75 | RAF1 (0.32) | TLR8TLR7 | |
| SCHEMBL30867920 | 0.75 | GPR119 (0.43) | — | |
| Hydrochloric Acid SCHEMBL20292047 | 0.72 | HTR1A (0.46) | HTR1ASLC6A2SLC6A4HTR6HTR2C | |
| SCHEMBL30867973 | 0.72 | ALOX5 (0.31) | — | |
| SCHEMBL30867762 | 0.70 | PDE4A (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598917-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| EP-4598916-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076674-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |
| WO-2024076672-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |