Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 9/20 | 0.48 |
| ▸ | MMP9 | P14780 | 9/20 | 0.48 |
| ▸ | MMP13 | P45452 | 6/20 | 0.48 |
| ▸ | MMP14 | P50281 | 6/20 | 0.48 |
| ▸ | MMP3 | P08254 | 5/20 | 0.48 |
| ▸ | MMP8 | P22894 | 5/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL230582 | 0.88 | KIF11 (0.55) | CA1CA2CA9MMP1KIF11 | |
| SCHEMBL15568689 | 0.86 | KIF11 (0.53) | CA1CA2CA9MMP1KIF11 | |
| SCHEMBL6115108 | 0.86 | KIF11 (0.53) | CA1CA2CA9MMP1KIF11 | |
| Hydrochloric Acid SCHEMBL4589695 | 0.86 | KIF11 (0.53) | CA1CA2CA9MMP1KIF11 | |
| SCHEMBL6306030 | 0.84 | ENPP3 (0.56) | CA1CA2CA9KIF11ALDH1A1 | |
| Ethylene SCHEMBL28421049 | 0.84 | KIF11 (0.52) | CA1CA2CA9MMP1KIF11 | |
| SCHEMBL6090901 | 0.84 | ALDH1A1 (0.58) | ALDH1A1HTTNPC1LMNATP53 | |
| SCHEMBL9249636 | 0.84 | ALDH1A1 (0.58) | ALDH1A1HTTNPC1LMNATP53 | |
| SCHEMBL2894832 | 0.82 | KIF11 (0.66) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL28521152 | 0.82 | ALDH1A1 (0.56) | ALDH1A1HTTNPC1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240083903-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | MERCK SHARP & DOHME LLC (US) | 2024-03-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240083903-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | TEAD2, TEAD3, TEAD4 | CA1 4707/4885CA2 2371/4885CA9 1942/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.