Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.32 |
| ▸ | GPR6 | P46095 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3959818 | 1.00 | DRD2 (0.39) | DRD2HTR1AHTR2ADRD3NAMPT | |
| SCHEMBL3086254 | 0.88 | DRD2 (0.46) | DRD2HTR1AHTR2ADRD3CACNA1I | |
| SCHEMBL3967377 | 0.88 | DRD2 (0.46) | DRD2HTR1AHTR2ADRD3CACNA1I | |
| SCHEMBL14715685 | 0.84 | OPRK1 (0.38) | NAMPTCACNA1I | |
| SCHEMBL3959814 | 0.84 | OPRK1 (0.38) | NAMPTCACNA1I | |
| SCHEMBL3086252 | 0.84 | GRM2 (0.47) | DRD2GRM2SLC6A4GPR6 | |
| SCHEMBL14715699 | 0.84 | GRM2 (0.47) | DRD2GRM2SLC6A4GPR6 | |
| SCHEMBL3963647 | 0.82 | DRD2 (0.39) | DRD2HTR1AHTR2ADRD3NAMPT | |
| SCHEMBL3087227 | 0.82 | DRD2 (0.39) | DRD2HTR1AHTR2ADRD3NAMPT | |
| SCHEMBL3067860 | 0.81 | HTR7 (0.46) | DRD2HTR2ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079693-B1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | claimed |
| US-7795437-B2 | Ether derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-09-14 | — | — | US | disclosed |