Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.50 |
| ▸ | CDK4 | P11802 | 2/20 | 0.49 |
| ▸ | CCND1 | P24385 | 2/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KIF11 | P52732 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25679865 | 0.76 | KIF11 (0.66) | ACHECDK4CCND1MAPTKIF11 | |
| SCHEMBL972999 | 0.76 | ACHE (0.78) | ACHEMAPTKIF11PARP1AURKA | |
| SCHEMBL29642993 | 0.76 | ACHE (0.78) | ACHEMAPTKIF11PARP1AURKA | |
| SCHEMBL29478498 | 0.72 | CHUK (0.73) | ACHEMAPTKIF11PARP1AURKA | |
| SCHEMBL12590220 | 0.72 | CHUK (0.73) | ACHEMAPTKIF11PARP1AURKA | |
| SCHEMBL27199799 | 0.71 | ACHE (0.50) | ACHECDK4CCND1MAPTKIF11 | |
| SCHEMBL445595 | 0.71 | IMPDH2 (0.58) | CDK4CCND1CDC7PDE3BPDE3A | |
| SCHEMBL23098918 | 0.70 | ACHE (0.58) | ACHECDK4CCND1MAPTKIF11 | |
| SCHEMBL13100680 | 0.70 | KIF11 (0.62) | ACHEMAPTKIF11PARP1MAPK1 | |
| SCHEMBL15133570 | 0.69 | PARP1 (0.55) | ACHECDK4CCND1MAPTPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4608401-A2 | MK2 INHIBITORS AND USES THEREOF | Bristol-Myers Squibb Company (US) | 2025-09-03 | — | — | EP | disclosed |
| US-20240190890-A1 | MK2 INHIBITORS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2024-06-13 | — | — | US | disclosed |
| WO-2024092115-A2 | MK2 INHIBITORS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240190890-A1 | MK2 INHIBITORS AND USES THEREOF | MKNK2, CSNK1G2, CSNK2A2 | ACHE 3609/4885CDK4 233/4885CCND1 1858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.