Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NPR1 | P16066 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20085592 | 1.00 | MAPT (0.41) | MAPTTHRBNPC1LMNARAB9A | |
| SCHEMBL20085591 | 0.88 | MAPT (0.33) | MAPTTHRBNPC1LMNARAB9A | |
| SCHEMBL8182091 | 0.82 | BLM (0.51) | MAPTTHRBLMNATP53CYP1A2 | |
| SCHEMBL13377639 | 0.81 | THRB (0.36) | MAPTTHRBNPC1TP53CYP1A2 | |
| SCHEMBL20085567 | 0.78 | MAPT (0.36) | MAPTTHRBTP53CYP1A2CYP3A4 | |
| SCHEMBL30880231 | 0.76 | MAPT (0.39) | MAPTTHRBNPC1LMNARAB9A | |
| SCHEMBL656009 | 0.76 | MAPT (0.39) | MAPTTHRBNPC1LMNARAB9A | |
| SCHEMBL13383865 | 0.75 | PIK3CD (0.36) | MAPTTHRBNPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL16601607 | 0.73 | GABRG2 (0.35) | MAPTTHRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13253422 | 0.73 | LMNA (0.39) | MAPTTHRBNPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117964639-A | Pyridazine compound containing benzo heterocyclic structure, pharmaceutical composition and application thereof | 中国药科大学 | 2024-05-03 | — | — | CN | disclosed |