Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.50 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127579 | 0.97 | CYP1A2 (0.52) | CYP1A2CYP1A1CYP1B1CALM1TSHR | |
| SCHEMBL4406066 | 0.88 | CYP1A2 (0.46) | CYP1A2CYP1A1CYP1B1CALM1TSHR | |
| Cyanide SCHEMBL21808145 | 0.88 | CYP1A1 (0.52) | CYP1A2CYP1A1CYP1B1CALM1TSHR | |
| SCHEMBL28309638 | 0.82 | TP53 (0.46) | CYP1A2CYP1A1CYP1B1CALM1TSHR | |
| SCHEMBL1127627 | 0.82 | FNTA (0.54) | CYP1A2IDO1CA1CA2CA9 | |
| SCHEMBL28309640 | 0.80 | TP53 (0.44) | CYP1A2CYP1A1CYP1B1CALM1TSHR | |
| Bisbenzyldiselenide SCHEMBL441260 | 0.78 | CYP1A1 (0.52) | CYP1A2CYP1A1CYP1B1CALM1TSHR | |
| SCHEMBL28859310 | 0.76 | CYP1A2 (0.41) | CYP1A2CYP1A1CYP1B1CALM1TSHR | |
| SCHEMBL28452710 | 0.76 | TP53 (0.46) | CYP1A2CYP1A1CYP1B1CALM1TSHR | |
| Bisbenzyldiselenide SCHEMBL29169728 | 0.75 | CYP1A1 (0.56) | CYP1A2CYP1A1CYP1B1CALM1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292490-A1 | A PROCESS FOR PRODUCING GAMMA MANGOSTIN | LAILA NUTRACEUTICALS (IN) | 2010-11-18 | — | — | US | claimed |
| WO-2009093259-A2 | A PROCESS FOR PRODUCING γ-MANGOSTIN | GOKARAJU GANGA RAJU (IN) | 2009-07-30 | — | — | WO | claimed |
| US-20180186748-A1 | CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF PHENYL-PYRAZOLES USEFUL AS MODULATERS OF THE 5-HT2A SEROTONIN RECEPTOR | ARENA PHARMACEUTICALS, INC. | 2018-07-05 | — | — | US | disclosed |
| US-9783502-B2 | Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-HT2A serotonin receptor | ARENA PHARMACEUTICALS, INC. (US) | 2017-10-10 | — | — | US | disclosed |
| US-20160272591-A1 | CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF PHENYL-PYRAZOLES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | ARENA PHARMACEUTICALS, INC. | 2016-09-22 | — | — | US | disclosed |
| US-9199940-B2 | Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-HT2A serotonin receptor | ARENA PHARMACEUTICALS, INC. (US) | 2015-12-01 | — | — | US | disclosed |
| EP-2018372-B1 | CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF PHENYL-PYRAZOLES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | ARENA PHARM INC (US) | 2015-05-13 | — | — | EP | disclosed |
| US-20130296321-A1 | CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF PHENYL-PYRAZOLES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | ARENA PHARMACEUTICALS, INC. | 2013-11-07 | — | — | US | disclosed |
| US-8481535-B2 | Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-HT2A serotonin receptor | ARENA PHARMACEUTICALS, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-20100234380-A1 | CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF PHENYL-PYRAZOLES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | ARENA PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | US | disclosed |
| EP-2018372-A2 | CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF PHENYL-PYRAZOLES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | Arena Pharmaceuticals, Inc. (US) | 2009-01-28 | — | — | EP | disclosed |
| WO-2007136689-A2 | CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF PHENYL-PYRAZOLES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-29 | — | — | WO | disclosed |
| US-4900782-A | Stabilized polyelectrolyte precursors of poly(aromatic and heteroaromatic vinylenes) | ALLIED-SIGNAL INC. (US) | 1990-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296321-A1 | CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF PHENYL-PYRAZOLES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | HTR2A, HTR5A, HTR2C | CYP1A2 29/4885CYP1A1 89/4885CYP1B1 52/4885 |
| US-20180186748-A1 | CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF PHENYL-PYRAZOLES USEFUL AS MODULATERS OF THE 5-HT2A SEROTONIN RECEPTOR | HTR2A, HTR5A, HTR2C | CYP1A2 35/4885CYP1A1 124/4885CYP1B1 95/4885 |
| US-20100292490-A1 | A PROCESS FOR PRODUCING GAMMA MANGOSTIN | SOST, CYP51A1, GNMT | CYP1A2 560/4885CYP1A1 307/4885CYP1B1 715/4885 |
| US-20100234380-A1 | CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF PHENYL-PYRAZOLES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | HTR2A, HTR5A, HTR2C | CYP1A2 29/4885CYP1A1 89/4885CYP1B1 52/4885 |
| US-20160272591-A1 | CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF PHENYL-PYRAZOLES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | HTR2A, HTR5A, HTR2C | CYP1A2 29/4885CYP1A1 89/4885CYP1B1 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.