Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11407221 | 0.84 | AKR1C3 (0.67) | AKR1C3SMN1; SMN2POLBMAPTMEN1 | |
| SCHEMBL6064618 | 0.84 | AKR1C3 (0.67) | AKR1C3SMN1; SMN2POLBMAPTMEN1 | |
| SCHEMBL351852 | 0.84 | AKR1C3 (0.67) | AKR1C3SMN1; SMN2POLBMAPTMEN1 | |
| SCHEMBL7701386 | 0.81 | CES2 (0.60) | AKR1C3SMN1; SMN2POLBMAPTMEN1 | |
| SCHEMBL7701390 | 0.81 | CES2 (0.60) | AKR1C3SMN1; SMN2POLBMAPTMEN1 | |
| SCHEMBL27323920 | 0.80 | CES2 (0.63) | AKR1C3SMN1; SMN2POLBPARP1MAPT | |
| SCHEMBL31529061 | 0.79 | CES2 (0.65) | SMN1; SMN2POLBPARP1MAPTMEN1 | |
| SCHEMBL3753584 | 0.79 | CES2 (0.65) | SMN1; SMN2POLBPARP1MAPTMEN1 | |
| SCHEMBL20608267 | 0.77 | AKR1C3 (0.53) | AKR1C3SMN1; SMN2POLBPARP1MAPT | |
| SCHEMBL3753879 | 0.76 | PARP1 (0.68) | SMN1; SMN2POLBPARP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4611899-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | Petra Pharma Corporation (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024097172-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | PETRA PHARMA CORPORATION (US) | 2024-05-10 | — | — | WO | disclosed |