Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.67 |
| ▸ | CES2 | O00748 | 4/20 | 0.56 |
| ▸ | CES1 | P23141 | 4/20 | 0.56 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL351852 | 1.00 | AKR1C3 (0.67) | AKR1C3CES2CES1AKR1C1ALDH1A1 | |
| SCHEMBL11407221 | 1.00 | AKR1C3 (0.67) | AKR1C3CES2CES1AKR1C1ALDH1A1 | |
| SCHEMBL14033873 | 0.90 | AKR1C3 (0.55) | AKR1C3CES2CES1AKR1C1ALDH1A1 | |
| SCHEMBL7701390 | 0.89 | CES2 (0.60) | AKR1C3CES2CES1ALDH1A1KMT2A | |
| SCHEMBL7701386 | 0.89 | CES2 (0.60) | AKR1C3CES2CES1ALDH1A1KMT2A | |
| SCHEMBL20415255 | 0.87 | CES2 (0.58) | AKR1C3CES2CES1AKR1C1ALDH1A1 | |
| SCHEMBL27301045 | 0.84 | CES2 (0.64) | AKR1C3CES2CES1ALDH1A1KMT2A | |
| SCHEMBL30889666 | 0.84 | AKR1C3 (0.53) | AKR1C3AKR1C1ALDH1A1KMT2AMAPT | |
| Styrene SCHEMBL27578113 | 0.84 | ALDH1A1 (0.49) | AKR1C3CES2CES1AKR1C1ALDH1A1 | |
| SCHEMBL27588182 | 0.83 | CES2 (0.49) | AKR1C3CES2CES1AKR1C1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115043720-B | Novel alpha-methyl chalcone compound and preparation method and application thereof | 新疆医科大学 | 2023-11-21 | — | — | CN | claimed |
| CN-115043720-A | Novel alpha-methyl chalcone compound and preparation method and application thereof | 新疆医科大学 | 2022-09-13 | — | — | CN | claimed |
| CN-115043720-B | Novel alpha-methyl chalcone compound and preparation method and application thereof | 新疆医科大学 | 2023-11-21 | — | — | CN | disclosed |
| CN-115043720-B | Novel alpha-methyl chalcone compound and preparation method and application thereof | 新疆医科大学 | 2023-11-21 | — | — | CN | disclosed |
| CN-115043720-B | Novel alpha-methyl chalcone compound and preparation method and application thereof | 新疆医科大学 | 2023-11-21 | — | — | CN | disclosed |
| CN-115043720-A | Novel alpha-methyl chalcone compound and preparation method and application thereof | 新疆医科大学 | 2022-09-13 | — | — | CN | disclosed |
| CN-115043720-A | Novel alpha-methyl chalcone compound and preparation method and application thereof | 新疆医科大学 | 2022-09-13 | — | — | CN | disclosed |
| CN-115043720-A | Novel alpha-methyl chalcone compound and preparation method and application thereof | 新疆医科大学 | 2022-09-13 | — | — | CN | disclosed |
| US-20120029197-A1 | Method for Preparing Sulfur-Containing Compounds | THE ROYAL COLLEGE OF SURGEONS IN IRELAND (IE) | 2012-02-02 | — | — | US | disclosed |
| US-20120029197-A1 | Method for Preparing Sulfur-Containing Compounds | THE ROYAL COLLEGE OF SURGEONS IN IRELAND (IE) | 2012-02-02 | — | — | US | disclosed |
| WO-2010066450-A1 | A METHOD FOR PREPARING SULFUR-CONTAINING COMPOUNDS | THE ROYAL COLLEGE OF SURGEONS IN IRELAND (IE) | 2010-06-17 | — | — | WO | disclosed |
| US-7084281-B2 | Synthesis of dihalohydrins and tri- and tetra-substituted olefins | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2006-08-01 | — | — | US | disclosed |
| US-20040143125-A1 | Synthesis of dihalohydrins and tri- and tetra-substituted olefins | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2004-07-22 | — | — | US | disclosed |
| EP-0662968-B1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES INC (US) | 1998-12-02 | — | — | EP | disclosed |
| EP-0662968-A1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1995-07-19 | — | — | EP | disclosed |
| EP-0662968-A4 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS. | PPG INDUSTRIES INC (US) | 1995-04-12 | — | — | EP | disclosed |
| WO-1994007889-A1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1994-04-14 | — | — | WO | disclosed |
| US-5274132-A | Photochromic naphthopyran compounds | TRANSITIONS OPTICAL, INC. (US) | 1993-12-28 | — | — | US | disclosed |
| US-4014896-A | Catalytic dehydrogenation process for the preparation of 3,4,5-trisubstituted pyrazoles | AMERICAN CYANAMID COMPANY (US) | 1977-03-29 | — | — | US | disclosed |
| US-3989708-A | HYPOTENSIVE, CORONARY VESSEL DILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120029197-A1 | Method for Preparing Sulfur-Containing Compounds | SULT1E1, SULT1A1, TST | AKR1C3 817/4885CES2 2121/4885CES1 1076/4885 |
| US-20040143125-A1 | Synthesis of dihalohydrins and tri- and tetra-substituted olefins | TALDO1, HDHD5, TKT | AKR1C3 172/4885CES2 324/4885CES1 318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.