Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.59 |
| ▸ | HTT | P42858 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30349789 | 0.80 | MAPT (0.61) | MAPTHTTLMNAKDM4ENPSR1 | |
| SCHEMBL28991107 | 0.80 | MAPT (0.61) | MAPTHTTLMNAKDM4ENPSR1 | |
| SCHEMBL15324212 | 0.79 | MAPT (0.59) | MAPTHTTLMNAKDM4ENPSR1 | |
| SCHEMBL15005983 | 0.79 | MAPT (0.59) | MAPTHTTLMNAKDM4ENPSR1 | |
| SCHEMBL1115747 | 0.79 | MAPT (0.59) | MAPTHTTLMNAKDM4ENPSR1 | |
| SCHEMBL28991080 | 0.76 | TDP1 (0.66) | MAPTHTTLMNAKDM4ENPSR1 | |
| SCHEMBL9379101 | 0.75 | MAPT (1.00) | MAPTHTTLMNAKDM4ENPSR1 | |
| SCHEMBL30993758 | 0.75 | MAPT (0.46) | MAPTHTTLMNAKDM4ENPSR1 | |
| SCHEMBL1115708 | 0.74 | MAPT (0.62) | MAPTHTTLMNAKDM4ENPSR1 | |
| SCHEMBL30896394 | 0.73 | LMNA (0.46) | MAPTHTTLMNAKDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612128-A1 | COMPOUNDS AND THEIR USE FOR TREATMENT OF HEMOGLOBINOPATHIES | Bristol-Myers Squibb Company (US) | 2025-09-10 | — | — | EP | disclosed |
| CN-120129677-A | Compounds and their use for the treatment of heme lesions | 百时美施贵宝公司 | 2025-06-10 | — | — | CN | disclosed |
| WO-2024097932-A1 | COMPOUNDS AND THEIR USE FOR TREATMENT OF HEMOGLOBINOPATHIES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-05-10 | — | — | WO | disclosed |