SCHEMBL1115708

SCHEMBL1115708

Cn1c(=O)n(CCCn2c(=O)n(C)c3cc([N+](=O)[O-])c([N+](=O)[O-])cc32)c2cc([N+](=O)[O-])c([N+](=O)[O-])cc21

nearest known ligand 0.62

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 7/20 0.62
▸ LMNA P02545 4/20 0.62
▸ HTT P42858 4/20 0.62
▸ KDM4E B2RXH2 1/20 0.62
▸ NPSR1 Q6W5P4 1/20 0.62
▸ SMN1; SMN2 Q16637 6/20 0.47
▸ ALDH1A1 P00352 5/20 0.45
▸ KMT2A Q03164 1/20 0.45
▸ PKM P14618 4/20 0.42
▸ CYP1A2 P05177 1/20 0.41
▸ GAA P10253 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ TDP1 Q9NUW8 1/20 0.38
▸ BCHE P06276 1/20 0.38
▸ ACHE P22303 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12314599 0.89 MAPT (0.50) MAPTLMNAHTTKDM4ENPSR1
SCHEMBL9379101 0.77 MAPT (1.00) MAPTLMNAHTTKDM4ENPSR1
SCHEMBL20569191 0.75 MAPT (0.42) MAPTLMNAHTTKDM4ENPSR1
SCHEMBL1115528 0.75 ALDH1A1 (0.42) MAPTLMNAHTTKDM4ENPSR1
SCHEMBL28991107 0.75 MAPT (0.61) MAPTLMNAHTTKDM4ENPSR1
SCHEMBL30349789 0.75 MAPT (0.61) MAPTLMNAHTTKDM4ENPSR1
SCHEMBL1115747 0.74 MAPT (0.59) MAPTLMNAHTTKDM4ENPSR1
SCHEMBL15005983 0.74 MAPT (0.59) MAPTLMNAHTTKDM4ENPSR1
SCHEMBL30896387 0.74 MAPT (0.59) MAPTLMNAHTTKDM4ENPSR1
SCHEMBL15324212 0.74 MAPT (0.59) MAPTLMNAHTTKDM4ENPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8262949-B2 Long wavelength shifted benzotriazole uv-absorbers and their use BASF SE (DE) 2012-09-11 — — US disclosed
US-8262949-B2 Long wavelength shifted benzotriazole uv-absorbers and their use BASF SE (DE) 2012-09-11 — — US disclosed
EP-2032577-B1 LONG WAVELENGTH SHIFTED BENZOTRIAZOLE UV-ABSORBERS AND THEIR USE BASF SE (DE) 2011-02-02 — — EP disclosed
EP-2032577-B1 LONG WAVELENGTH SHIFTED BENZOTRIAZOLE UV-ABSORBERS AND THEIR USE BASF SE (DE) 2011-02-02 — — EP disclosed
US-20100163813-A1 Long wavelength shifted benzotriazole uv-absorbers and their use CIBA CORPORATION 2010-07-01 — — US disclosed
US-20100163813-A1 Long wavelength shifted benzotriazole uv-absorbers and their use CIBA CORPORATION 2010-07-01 — — US disclosed
WO-2008000646-A1 LONG WAVELENGTH SHIFTED BENZOTRIAZOLE UV-ABSORBERS AND THEIR USE CIBA HOLDING INC. (CH) 2008-01-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100163813-A1 Long wavelength shifted benzotriazole uv-absorbers and their use SULT1A1, GABBR1, TPMT MAPT 136/4885LMNA 1593/4885HTT 292/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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