Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 5/20 | 0.52 |
| ▸ | PGK2 | P07205 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | INPPL1 | O15357 | 2/20 | 0.36 |
| ▸ | INPP5A | Q14642 | 2/20 | 0.36 |
| ▸ | INPP5B | P32019 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10977732 | 0.80 | PGK1 (0.43) | PGK1PGK2TSHRCYP3A4MAPK1 | |
| Phosphoric Acid SCHEMBL29023595 | 0.79 | PGK1 (0.52) | PGK1PGK2TSHRCYP3A4MAPK1 | |
| Phosphoric Acid SCHEMBL15475844 | 0.79 | PGK1 (0.52) | PGK1PGK2TSHRCYP3A4MAPK1 | |
| Methyl Alcohol SCHEMBL21899428 | 0.76 | CYP3A4 (0.50) | PGK1PGK2TSHRCYP3A4MAPK1 | |
| Phosphoric Acid SCHEMBL27654488 | 0.76 | — | — | |
| Phosphoric Acid SCHEMBL31047197 | 0.76 | PGK1 (0.50) | PGK1PGK2TSHRCYP3A4MAPK1 | |
| SCHEMBL39444 | 0.76 | TSHR (0.57) | TSHRCYP3A4MAPK1CA2GRIN2D | |
| SCHEMBL8109982 | 0.76 | TSHR (0.57) | TSHRCYP3A4MAPK1CA2GRIN2D | |
| SCHEMBL8386869 | 0.74 | PGK1 (0.46) | PGK1PGK2TSHRCYP3A4MAPK1 | |
| O-Xylene SCHEMBL17255245 | 0.73 | TSHR (0.62) | PGK1PGK2TSHRLMNASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024067465-A1 | KIF18A INHIBITOR | 山东轩竹医药科技有限公司 | 2024-04-04 | — | — | WO | disclosed |