Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.31 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6486053 | 0.81 | HCRTR1 (0.37) | HCRTR1HCRTR2PDE2ANPC1CYP1A2 | |
| SCHEMBL16804955 | 0.79 | DHFR (0.38) | HCRTR1HCRTR2PDE2ANPC1CYP1A2 | |
| Hydrochloric Acid SCHEMBL10953059 | 0.78 | NOS3 (0.43) | SMN1; SMN2 | |
| SCHEMBL24760166 | 0.77 | SMN1; SMN2 (0.33) | SMN1; SMN2 | |
| SCHEMBL30707665 | 0.77 | AHR (0.32) | — | |
| SCHEMBL16783064 | 0.76 | ALDH1A1 (0.33) | HCRTR1HCRTR2PDE2ASMN1; SMN2NPC1 | |
| SCHEMBL27272806 | 0.75 | KMT2A (0.34) | MAPTUHRF1 | |
| SCHEMBL30907243 | 0.75 | MEN1 (0.36) | HCRTR1HCRTR2PDE2AMAPT | |
| SCHEMBL27862145 | 0.75 | HCRTR1 (0.34) | HCRTR1HCRTR2PDE2A | |
| SCHEMBL13859138 | 0.75 | HCRTR1 (0.34) | HCRTR1HCRTR2PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024097953-A1 | NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES | ENLIVEN INC. (US) | 2024-05-10 | — | — | WO | disclosed |