Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4636092 | 0.76 | KDM4E (0.49) | HCAR3HDAC4KDM4EGLAHTT | |
| Lithium Ion SCHEMBL20589049 | 0.73 | HPGDS (0.54) | HIPK2 | |
| SCHEMBL1714095 | 0.72 | HCAR3 (0.46) | HCAR3HDAC4KDM4EGLAHTT | |
| SCHEMBL12791697 | 0.71 | MAPK1 (0.46) | KDM4EKMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL30908327 | 0.71 | CSNK1D (0.48) | — | |
| SCHEMBL17294856 | 0.71 | NNMT (0.44) | HDAC4KDM4ESMN1; SMN2L3MBTL1HSD11B1 | |
| SCHEMBL12640243 | 0.71 | HDAC4 (0.40) | HDAC4 | |
| Lithium Ion SCHEMBL16047036 | 0.69 | HDAC1 (0.55) | HCAR3HIPK2KDM4EHDAC3HDAC1 | |
| SCHEMBL24755952 | 0.67 | TDO2 (0.36) | HDAC4KDM4EGLAHTTKMT2A | |
| SCHEMBL11230605 | 0.67 | DEGS1 (0.37) | HDAC4KDM4EGLAHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024074611-A1 | PRMT5 INHIBITORS | Ryvu Therapeutics S.A. (PL) | 2024-04-11 | — | — | WO | disclosed |