SCHEMBL30908333

SCHEMBL30908333

O=C(O)c1ccc(C2(C(F)(F)F)CC2)nc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P4HA1 P13674 2/20 0.46
P4HTM Q9NXG6 2/20 0.46
L3MBTL1 Q9Y468 1/20 0.45
RARA P10276 1/20 0.45
RARB P10826 1/20 0.45
RARG P13631 1/20 0.45
RXRA P19793 1/20 0.45
RXRB P28702 1/20 0.45
PPARG P37231 1/20 0.45
RXRG P48443 1/20 0.45
MIF P14174 1/20 0.44
HCAR3 P49019 11/20 0.44
GABRP O00591 1/20 0.43
GABRD O14764 1/20 0.43
GABRA1 P14867 1/20 0.43
GABRB1 P18505 1/20 0.43
GABRG2 P18507 1/20 0.43
GABRB3 P28472 1/20 0.43
GABRA5 P31644 1/20 0.43
GABRA3 P34903 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29990008 1.00 P4HA1 (0.46) P4HA1P4HTML3MBTL1RARARARB
SCHEMBL30567625 0.86 MAPT (0.39) L3MBTL1RARARARBRARGRXRA
SCHEMBL29268179 0.82 MAPK1 (0.50) L3MBTL1ALDH1A1MAPT
SCHEMBL29989233 0.82 MAPK1 (0.50) L3MBTL1ALDH1A1MAPT
SCHEMBL29989449 0.79 ALDH1A1 (0.42) L3MBTL1RARARARBRARGRXRA
SCHEMBL29268034 0.78 GABRP (0.49) P4HTMRXRARXRBRXRGGABRP
SCHEMBL17594690 0.76 KDM4C (0.49) P4HA1GABRPGABRDGABRA1GABRB1
SCHEMBL28384854 0.76 RXRA (0.56) P4HA1P4HTMRARARARBRARG
SCHEMBL13804209 0.75 GABRP (0.52) P4HA1P4HTMRARARARBRARG
SCHEMBL15505012 0.74 TSHR (0.46) RXRARXRBRXRGNAPRTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4720060-A1 PRMT5 INHIBITORS Ryvu Therapeutics S.A. (PL) 2026-04-08 EP disclosed
WO-2024240894-A1 PRMT5 INHIBITORS Ryvu Therapeutics S.A. (PL) 2024-11-28 WO disclosed
WO-2024074611-A1 PRMT5 INHIBITORS Ryvu Therapeutics S.A. (PL) 2024-04-11 WO disclosed