Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38653347 | 0.75 | LMNA (0.38) | LMNAPOLBSMN1; SMN2GPR119ALDH1A1 | |
| SCHEMBL30911167 | 0.73 | GPR119 (0.46) | LMNAGPR119PIK3R1PIK3CA | |
| SCHEMBL30911135 | 0.73 | GPR119 (0.46) | LMNAGPR119PIK3R1PIK3CA | |
| SCHEMBL38654099 | 0.72 | GPR119 (0.46) | LMNAGPR119PIK3R1PIK3CA | |
| SCHEMBL30911096 | 0.72 | SMARCA2 (0.48) | LMNAGPR119PIK3R1PIK3CA | |
| SCHEMBL18149413 | 0.71 | GPR119 (0.41) | LMNAPOLBSMN1; SMN2GPR119PIK3R1 | |
| SCHEMBL30019205 | 0.70 | HRH3 (0.43) | GPR119MMP1MMP3MMP7MMP9 | |
| SCHEMBL30911128 | 0.69 | GPR119 (0.45) | LMNAGPR119ALDH1A1MMP1MMP3 | |
| SCHEMBL2570900 | 0.68 | POLB (0.51) | LMNAPOLBSMN1; SMN2ALDH1A1MMP1 | |
| SCHEMBL11963107 | 0.67 | GRM1 (0.39) | LMNAPOLBSMN1; SMN2GPR119ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598915-A2 | TETHERED HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076670-A2 | TETHERED HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |