Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | NOS3 | P29474 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15884492 | 1.00 | ADRA2C (0.58) | ADRA2CKDM4EGAAMAPTPTK2B | |
| SCHEMBL23770737 | 0.82 | CHRNB2 (0.47) | KDM4EGAAMAPTALDH1A1KMT2A | |
| SCHEMBL24534142 | 0.82 | CHRNB2 (0.47) | KDM4EGAAMAPTALDH1A1KMT2A | |
| SCHEMBL15884424 | 0.81 | MEN1 (0.48) | KDM4EGAAMAPTALDH1A1KMT2A | |
| SCHEMBL6883566 | 0.79 | NOS3 (0.51) | ADRA2CKDM4EGAAMAPTPTK2B | |
| SCHEMBL22712693 | 0.78 | ADRA2C (0.68) | ADRA2CKDM4EGAAMAPTPTK2B | |
| SCHEMBL2013498 | 0.78 | ADRA2C (0.68) | ADRA2CKDM4EGAAMAPTPTK2B | |
| SCHEMBL24783781 | 0.78 | HTR3A (0.45) | ADRA2CGAAALDH1A1KMT2ANOS3 | |
| SCHEMBL3453464 | 0.78 | CHRNB2 (0.64) | ADRA2CGAANOS3NOS1HTR3A | |
| SCHEMBL24309749 | 0.78 | CHRNB2 (0.57) | ADRA2CNOS3NOS1HTR3ACYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4619406-A1 | TRICYCLIC COMPOUNDS | Schrödinger, Inc. (US) | 2025-09-24 | — | — | EP | disclosed |
| WO-2024107393-A1 | TRICYCLIC COMPOUNDS | SCHRÖDINGER, INC. (US) | 2024-05-23 | — | — | WO | disclosed |