Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | CTSV | O60911 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSH | P09668 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | CASP4 | P49662 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | CTSZ | Q9UBR2 | 1/20 | 0.36 |
| ▸ | KLK4 | Q9Y5K2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | AR | P10275 | 3/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30914204 | 0.82 | NPC1 (0.40) | KDM4EHIF1ANPSR1CTSLCTSS | |
| SCHEMBL30914201 | 0.81 | MEN1 (0.46) | KDM4EHIF1ANPSR1CTSLCTSS | |
| SCHEMBL31203032 | 0.79 | KDM4E (0.37) | KDM4EHIF1ANPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9129588 | 0.69 | USP2 (0.45) | KDM4ENPC1ARRAB9AALDH1A1 | |
| SCHEMBL10129568 | 0.68 | CYP17A1 (0.45) | CYP17A1ALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL16923740 | 0.68 | RPS6KA5 (0.40) | KDM4ENPC1CYP17A1RAB9AALDH1A1 | |
| SCHEMBL14723302 | 0.67 | CYP2C19 (0.47) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL11335130 | 0.67 | NPC1 (0.41) | KDM4ENPC1CYP17A1RAB9AALDH1A1 | |
| SCHEMBL5085214 | 0.67 | NPC1 (0.48) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL9125446 | 0.65 | PGK1 (0.47) | KDM4ENPC1ARRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12421218-B2 | Substituted pyrazine-carboxamide derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2025-09-23 | — | — | US | disclosed |
| US-20240417394-A1 | NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2024-12-19 | — | — | US | disclosed |
| US-20240182453-A1 | NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE DERIVATIVES | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2024-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12421218-B2 | Substituted pyrazine-carboxamide derivatives | GRM4, GRIA4, GRM1 | KDM4E 1273/4885HIF1A 1532/4885NPSR1 220/4885 |
| US-20240417394-A1 | NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE DERIVATIVES | GRIA4, GRM4, GRM1 | KDM4E 1122/4885HIF1A 1551/4885NPSR1 200/4885 |
| US-20240182453-A1 | NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE DERIVATIVES | GRIA4, GRM4, GRM1 | KDM4E 1122/4885HIF1A 1551/4885NPSR1 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.