Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | CTSZ | Q9UBR2 | 1/20 | 0.40 |
| ▸ | KLK4 | Q9Y5K2 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 12/20 | 0.37 |
| ▸ | AR | P10275 | 3/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30914197 | 0.82 | KDM4E (0.41) | NPC1CTSLCTSSRAB9ACTSC | |
| SCHEMBL30914201 | 0.77 | MEN1 (0.46) | NPC1CTSLCTSSRAB9AKDM4E | |
| SCHEMBL31203106 | 0.75 | POLB (0.37) | NPC1CTSLELANECMA1CTSS | |
| SCHEMBL31203032 | 0.74 | KDM4E (0.37) | KDM4EHIF1ANPSR1 | |
| SCHEMBL21555711 | 0.64 | ADORA2A (0.36) | NPC1CTSLELANECMA1CTSS | |
| SCHEMBL14723302 | 0.63 | CYP2C19 (0.47) | NPC1RAB9AKDM4EMAPK1 | |
| SCHEMBL30899625 | 0.62 | PRPS1 (0.43) | TGFBR1PRPS1 | |
| SCHEMBL15758260 | 0.61 | FFAR1 (0.42) | AR | |
| SCHEMBL31748263 | 0.61 | TDP1 (0.63) | MAPK1 | |
| SCHEMBL8466888 | 0.61 | PRPS1 (0.34) | TGFBR1PRPS1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12421218-B2 | Substituted pyrazine-carboxamide derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2025-09-23 | — | — | US | disclosed |
| US-20240417394-A1 | NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2024-12-19 | — | — | US | disclosed |
| US-20240182453-A1 | NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE DERIVATIVES | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2024-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12421218-B2 | Substituted pyrazine-carboxamide derivatives | GRM4, GRIA4, GRM1 | NPC1 1174/4885CTSL 4172/4885ELANE 4632/4885 |
| US-20240417394-A1 | NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE DERIVATIVES | GRIA4, GRM4, GRM1 | NPC1 1467/4885CTSL 4154/4885ELANE 4690/4885 |
| US-20240182453-A1 | NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE DERIVATIVES | GRIA4, GRM4, GRM1 | NPC1 1467/4885CTSL 4154/4885ELANE 4690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.