Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.51 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6252188 | 0.84 | IKBKB (0.67) | IKBKBALDH1A1KDM4EHPGDPPARG | |
| SCHEMBL31596262 | 0.79 | KDM4E (0.65) | ALDH1A1KDM4EHPGDPPARGSTAT3 | |
| SCHEMBL31350444 | 0.79 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDPPARGSTAT3 | |
| SCHEMBL16052627 | 0.77 | RAB9A (0.46) | IKBKBALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL1703147 | 0.77 | KDM4E (0.45) | IKBKBALDH1A1KDM4EGAAKDR | |
| SCHEMBL2816056 | 0.76 | IKBKB (0.47) | IKBKBALDH1A1KDM4EHPGDPPARG | |
| SCHEMBL25285293 | 0.73 | PTGES (0.41) | ALDH1A1POLBRAB9AATMHTT | |
| SCHEMBL2820504 | 0.72 | KDR (0.55) | IKBKBALDH1A1KDM4EHPGDGAA | |
| SCHEMBL2235616 | 0.71 | MEN1 (0.47) | IKBKBALDH1A1KDRHSD17B10LMNA | |
| SCHEMBL22208260 | 0.70 | SQOR (0.74) | IKBKBALDH1A1KDM4EHPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120058736-A | FLT3 covalent inhibitor containing isoxazolo [5,4-b ] pyridine structure and preparation method and application thereof | 南京中医药大学 | 2025-05-30 | — | — | CN | disclosed |
| CN-115710281-B | Isoxazolo [5,4-b ] pyridine FLT3 inhibitor and preparation method and application thereof | 南京中医药大学 | 2024-05-17 | — | — | CN | disclosed |