Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.36 |
| ▸ | HTR2A | P28223 | 6/20 | 0.33 |
| ▸ | HTR2B | P41595 | 6/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30917566 | 0.80 | S100A4 (0.37) | HTR2CHTR2AHTR2BTYMSMDM2 | |
| SCHEMBL10696858 | 0.75 | HTR2C (0.44) | HTR2CHTR2AHTR2BMAP3K14TAAR1 | |
| SCHEMBL31064577 | 0.70 | METAP1 (0.37) | HTR2CHTR2AHTR2BMETAP1SLC6A2 | |
| SCHEMBL28903977 | 0.67 | S100A4 (0.41) | TYMS | |
| SCHEMBL20624736 | 0.67 | TAAR1 (0.43) | HTR2CHTR2AHTR2BTAAR1ADRB1 | |
| SCHEMBL31040764 | 0.67 | PNMT (0.40) | HTR2CHTR2AHTR2BCHRNB2CHRNA4 | |
| SCHEMBL31064308 | 0.67 | PNMT (0.40) | HTR2CHTR2AHTR2BCHRNB2CHRNA4 | |
| SCHEMBL18533284 | 0.66 | MAOB (0.47) | METAP1ADRA2A | |
| SCHEMBL18995114 | 0.66 | HTR2C (0.49) | HTR2CHTR2AHTR2BMAP3K14ADRB1 | |
| SCHEMBL23542272 | 0.64 | TAAR1 (0.38) | HTR2CHTR2AHTR2BTAAR1ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4622716-A1 | SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2025-10-01 | — | — | EP | disclosed |
| WO-2024112654-A1 | SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2024-05-30 | — | — | WO | disclosed |