Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 2/20 | 0.37 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | VHL | P40337 | 1/20 | 0.36 |
| ▸ | ELOC | Q15369 | 1/20 | 0.36 |
| ▸ | ELOB | Q15370 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PPOX | P50336 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30917547 | 0.80 | HTR2C (0.36) | TYMSMDM2HTR2CHTR2AHTR2B | |
| SCHEMBL31040911 | 0.80 | ACHE (0.42) | HTR2CMAOBCYP19A1 | |
| SCHEMBL31040873 | 0.76 | TERT (0.39) | HTR2CHTR2AHTR2BTERTSRD5A1 | |
| SCHEMBL10696858 | 0.75 | HTR2C (0.44) | MDM2GAAHTR2CHTR2AHTR2B | |
| SCHEMBL30917688 | 0.75 | ALDH1A1 (0.44) | S100A4MAPTALDH1A1TDP1TERT | |
| SCHEMBL28903977 | 0.74 | S100A4 (0.41) | S100A4TYMSARGAAPPOX | |
| SCHEMBL27560253 | 0.71 | VHL (0.44) | S100A4TYMSVHLELOCELOB | |
| SCHEMBL31040901 | 0.70 | PBRM1 (0.43) | S100A4ARALDH1A1HTR2CHTR2A | |
| SCHEMBL31040926 | 0.70 | ACHE (0.39) | HTR2CMAOBHTR2A | |
| SCHEMBL31384990 | 0.68 | AR (0.40) | S100A4TYMSARVHLELOC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4622716-A1 | SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2025-10-01 | — | — | EP | disclosed |
| WO-2024112654-A1 | SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2024-05-30 | — | — | WO | disclosed |