Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3088526 | 0.89 | ALDH1A1 (0.45) | ALDH1A1RECQLG6PDLMNAGAA | |
| SCHEMBL3086378 | 0.87 | ALDH1A1 (0.49) | ALDH1A1RECQLG6PDGAAHDAC3 | |
| SCHEMBL3092574 | 0.83 | ALDH1A1 (0.58) | ALDH1A1RECQLLMNAGAAEPHX2 | |
| SCHEMBL3097296 | 0.82 | RECQL (0.44) | ALDH1A1RECQLG6PDCYP2C9SLC6A4 | |
| SCHEMBL3080743 | 0.81 | SLC6A4 (0.41) | ALDH1A1LMNAGAAEPHX2CYP2C9 | |
| SCHEMBL3092165 | 0.80 | KEAP1 (0.44) | ALDH1A1RECQLG6PDCYP2C9SLC6A4 | |
| SCHEMBL3090850 | 0.80 | CTSS (0.46) | ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL27747922 | 0.78 | LMNA (0.47) | ALDH1A1LMNAGAAEPHX2MEN1 | |
| SCHEMBL3092143 | 0.76 | SLC6A4 (0.39) | ALDH1A1RECQLEPHX2CYP2C9SLC6A4 | |
| SCHEMBL3097860 | 0.73 | ATM (0.43) | ALDH1A1GAACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799797-B2 | Arylsulfonyl naphthalene derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2010-09-21 | — | — | US | disclosed |
| EP-2041079-A1 | ARYLSULFONYL NAPHTHALENE DERIVATIVES AND USES THEREOF | F. Hoffmann-Roche AG (CH) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007147763-A1 | ARYLSULFONYL NAPHTHALENE DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-27 | — | — | WO | disclosed |