Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP3 | P15309 | 1/20 | 0.49 |
| ▸ | PGK1 | P00558 | 2/20 | 0.41 |
| ▸ | PGK2 | P07205 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP12 | P39900 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2420219 | 0.92 | ACP3 (0.55) | ACP3PGK1PGK2GRIN2DGRIN3B | |
| Butane SCHEMBL3810051 | 0.79 | TSHR (0.62) | ACP3PGK1PGK2TSHRGRIN2D | |
| SCHEMBL14732169 | 0.79 | ACP3 (0.46) | ACP3PGK1PGK2RIPK1GRIN2D | |
| SCHEMBL11499183 | 0.78 | ACP3 (0.57) | ACP3PGK1PGK2TSHRGRIN2D | |
| SCHEMBL8053801 | 0.77 | ACP3 (0.65) | ACP3PGK1PGK2TSHRGRIN2D | |
| SCHEMBL29707862 | 0.77 | ACP3 (0.65) | ACP3PGK1PGK2TSHRGRIN2D | |
| SCHEMBL21638770 | 0.77 | ACP3 (0.52) | ACP3PGK1PGK2GRIN2DGRIN3B | |
| Butane SCHEMBL11004584 | 0.75 | TSHR (0.47) | ACP3TSHRALDH1A1HSD17B10KMT2A | |
| SCHEMBL914880 | 0.74 | ENPP2 (0.50) | ACP3PGK1PGK2TSHRGRIN2D | |
| SCHEMBL2008228 | 0.73 | NPSR1 (0.41) | RIPK1TSHRTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227623-B2 | Process for the preparation of asenapine and intermediate products used in said process | MSD OSS B.V. (NL) | 2012-07-24 | — | — | US | disclosed |
| US-20100234618-A1 | Process for the Preparation of Asenapine and Intermediate Products Used in Said Process | N.V. ORGANON (NL) | 2010-09-16 | — | — | US | disclosed |
| US-7750167-B2 | Process for the preparation of asenapine and intermediate products used in said process | N.V. ORGANON (NL) | 2010-07-06 | — | — | US | disclosed |
| EP-2044076-B1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS. | ORGANON NV (NL) | 2009-10-14 | — | — | EP | disclosed |
| EP-2044076-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS. | N.V. Organon (NL) | 2009-04-08 | — | — | EP | disclosed |
| US-20080009619-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | N.V. ORGANON (NL) | 2008-01-10 | — | — | US | disclosed |
| WO-2008003460-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS. | N.V. ORGANON (NL) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009619-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | DHPS, CYP3A5, PNMT | ACP3 1479/4885PGK1 2351/4885PGK2 1751/4885 |
| US-20100234618-A1 | Process for the Preparation of Asenapine and Intermediate Products Used in Said Process | DHPS, CYP3A5, PNMT | ACP3 1479/4885PGK1 2351/4885PGK2 1751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.