Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3081465 | 1.00 | KMT2A (0.55) | KMT2AMEN1HDAC6HDAC1HDAC3 | |
| Hydrochloric Acid SCHEMBL27480577 | 0.88 | POLB (0.57) | KMT2AMEN1CA1CA2L3MBTL1 | |
| SCHEMBL6980785 | 0.86 | CA12 (0.59) | KMT2AMEN1CA1CA2KDM4E | |
| Hydrochloric Acid SCHEMBL6983894 | 0.84 | CA12 (0.57) | KMT2AMEN1CA1CA2KDM4E | |
| SCHEMBL7347503 | 0.80 | ITGB3 (0.60) | KMT2AMEN1HDAC6HDAC1HDAC3 | |
| SCHEMBL7423126 | 0.80 | POLB (0.45) | KMT2AMEN1CA1CA2LTA4H | |
| SCHEMBL7347966 | 0.79 | POLB (0.44) | KMT2AMEN1HDAC6HDAC1HDAC3 | |
| SCHEMBL7423108 | 0.78 | CA12 (0.44) | KMT2AMEN1CA1CA2L3MBTL1 | |
| SCHEMBL7345488 | 0.78 | ITGB3 (0.54) | KMT2AMEN1CA1CA2 | |
| SCHEMBL8075987 | 0.78 | KMT2A (0.58) | KMT2AHDAC6HDAC1HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267702-A1 | Bisbenzamidines and bisbenzamidoximes for the treatment of human African trypanosomiasis | HUANG TIEN L | 2010-10-21 | — | — | US | disclosed |
| WO-2008070831-A2 | BISBENZAMIDINES AND BISBENZAMIDOXIMES FOR THE TREATMENT OF HUMAN AFRICAN TRYPANOSOMIASIS | XAVIER UNIVERSITY OF LOUISIANA (US) | 2008-06-12 | — | — | WO | disclosed |
| US-20080139534-A1 | or sleeping sickness, caused by Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense; lethargy, continous sleep, breakdown of neurological function, coma and death; viricide, antiprotozoa agent; Pentamidine analog; topoisomerases II inhibitor; inhibit synthesis of DNA, RNA by parasites | XAVIER UNIVERSITY OF LOUISIANA (US) | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139534-A1 | or sleeping sickness, caused by Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense; lethargy, continous sleep, breakdown of neurological function, coma and death; viricide, antiprotozoa agent; Pentamidine analog; topoisomerases II inhibitor; inhibit synthesis of DNA, RNA by parasites | TOP2A, TOP2B, TOP1 | KMT2A 347/4885MEN1 3625/4885HDAC6 2252/4885 |
| US-20100267702-A1 | Bisbenzamidines and bisbenzamidoximes for the treatment of human African trypanosomiasis | PBRM1, TFB2M, ABAT | KMT2A 2067/4885MEN1 2518/4885HDAC6 1167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.