SCHEMBL30945490

SCHEMBL30945490

NC(=NC(=O)Nc1ccc(Cl)cc1Cl)Nc1nc2ccccc2s1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 1/20 0.59
KMT2A Q03164 5/20 0.53
MAPT P10636 3/20 0.53
CSNK1D P48730 2/20 0.52
NPC1 O15118 6/20 0.47
RAB9A P51151 6/20 0.47
POLB P06746 1/20 0.47
CASP3 P42574 3/20 0.47
SENP8 Q96LD8 3/20 0.47
SENP7 Q9BQF6 3/20 0.47
SENP6 Q9GZR1 3/20 0.47
MEN1 O00255 4/20 0.46
SMN1; SMN2 Q16637 4/20 0.46
KDM4E B2RXH2 3/20 0.46
GAA P10253 2/20 0.46
DYRK1A Q13627 2/20 0.46
ALDH1A1 P00352 1/20 0.46
ADORA1 P30542 1/20 0.46
FFAR2 O15552 1/20 0.46
DRD2 P14416 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30945507 0.89 RAB9A (0.51) DHODHKMT2AMAPTCSNK1DNPC1
SCHEMBL30945521 0.88 MEN1 (0.55) DHODHKMT2AMAPTCSNK1DNPC1
SCHEMBL30945504 0.84 CSNK1D (0.58) DHODHKMT2AMAPTCSNK1DNPC1
SCHEMBL30945526 0.82 RAB9A (0.54) DHODHKMT2AMAPTCSNK1DNPC1
SCHEMBL30945533 0.80 RAB9A (0.57) KMT2AMAPTCSNK1DNPC1RAB9A
SCHEMBL30945528 0.80 GAA (0.50) KMT2AMAPTCSNK1DNPC1RAB9A
SCHEMBL30945519 0.80 NPC1 (0.55) KMT2AMAPTNPC1RAB9APOLB
SCHEMBL30945518 0.79 MAPT (0.55) DHODHKMT2AMAPTCSNK1DNPC1
SCHEMBL30945514 0.78 BUB1 (0.53) KMT2AMAPTCSNK1DNPC1RAB9A
SCHEMBL13522371 0.78 CSNK1D (0.59) DHODHKMT2AMAPTCSNK1DNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4638427-A1 AMIDINOUREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER Université Côte d'Azur (FR) 2025-10-29 EP disclosed
WO-2024133857-A1 AMIDINOUREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER UNIVERSITE COTE D'AZUR (FR) 2024-06-27 WO disclosed