Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL4I1 | Q96RQ9 | 3/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30948088 | 0.82 | IL4I1 (0.40) | IL4I1DDB1CRBNP2RX7MAPT | |
| SCHEMBL30948347 | 0.80 | IL4I1 (0.39) | IL4I1DDB1CRBNPRMT5 | |
| SCHEMBL30947936 | 0.78 | IL4I1 (0.38) | IL4I1HCRTR2HCRTR1PRMT5ALDH1A1 | |
| SCHEMBL30948194 | 0.78 | CA12 (0.47) | IL4I1P2RX7HCRTR2MAPT | |
| SCHEMBL30948108 | 0.77 | IL4I1 (0.41) | IL4I1DDB1CRBNP2RX7HCRTR2 | |
| SCHEMBL30947928 | 0.76 | IL4I1 (0.60) | IL4I1PORCNMAPTPRMT5MEN1 | |
| SCHEMBL30948295 | 0.76 | GSK3B (0.39) | IL4I1HCRTR2HCRTR1 | |
| SCHEMBL30948202 | 0.75 | IL4I1 (0.40) | IL4I1CNR2DDB1CRBNHDAC6 | |
| SCHEMBL30948269 | 0.74 | IL4I1 (0.69) | IL4I1HDAC6HDAC1GRM2PORCN | |
| SCHEMBL30948186 | 0.73 | IL4I1 (0.62) | IL4I1P2RX7GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240246937-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2024-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246937-A1 | IL4I1 INHIBITORS AND METHODS OF USE | IL4I1, IL4, IL2 | IL4I1 1/4885CNR2 3878/4885DDB1 3807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.