Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30947936 | 0.86 | IL4I1 (0.38) | IL4I1PRMT5 | |
| SCHEMBL30948172 | 0.85 | IL4I1 (0.54) | IL4I1DYRK1APRMT5DDB1CRBN | |
| SCHEMBL30948295 | 0.84 | GSK3B (0.39) | IL4I1DYRK1A | |
| SCHEMBL30948260 | 0.80 | IL4I1 (0.46) | IL4I1PRMT5DDB1CRBN | |
| SCHEMBL30948174 | 0.78 | GRM2 (0.37) | IL4I1DYRK1APRMT5 | |
| SCHEMBL30948204 | 0.75 | IL4I1 (0.35) | IL4I1 | |
| SCHEMBL30047027 | 0.73 | IL4I1 (0.51) | IL4I1 | |
| SCHEMBL30947923 | 0.73 | IL4I1 (0.48) | IL4I1 | |
| SCHEMBL30947928 | 0.72 | IL4I1 (0.60) | IL4I1PRMT5 | |
| SCHEMBL30948108 | 0.71 | IL4I1 (0.41) | IL4I1DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240246937-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2024-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246937-A1 | IL4I1 INHIBITORS AND METHODS OF USE | IL4I1, IL4, IL2 | IL4I1 1/4885DYRK1A 4315/4885PRMT5 2408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.