Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | ESRRB | O95718 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESRRA | P11474 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30083142 | 0.92 | BACE1 (0.45) | LMNASMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL30952676 | 0.88 | USP30 (0.39) | LMNACYP2C19GPR119 | |
| SCHEMBL30952686 | 0.88 | RET (0.45) | SMN1; SMN2MEN1KMT2AMAPTTSHR | |
| SCHEMBL30952659 | 0.88 | RET (0.45) | SMN1; SMN2MEN1KMT2AMAPTTSHR | |
| SCHEMBL30952662 | 0.88 | RET (0.45) | SMN1; SMN2MEN1KMT2AMAPTTSHR | |
| SCHEMBL30083270 | 0.87 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL30083308 | 0.84 | GPR119 (0.45) | LMNASMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL30083193 | 0.80 | CTSS (0.49) | SMN1; SMN2MEN1KMT2ACYP2C19CTSS | |
| SCHEMBL30083219 | 0.80 | — | — | |
| SCHEMBL30083171 | 0.79 | RET (0.46) | GPR119CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024121709-A1 | PAPAIN-LIKE PROTEASE (PLPRO) INHIBITORS | PFIZER INC. (US) | 2024-06-13 | — | — | WO | disclosed |