Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 7/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | RECQL | P46063 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | BLM | P54132 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | THPO | P40225 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL31018188 | 0.98 | PNMT (0.68) | PNMTADRA2AADRA2BADRA2CDRD1 | |
| Bromide SCHEMBL3091461 | 0.98 | PNMT (0.68) | PNMTADRA2AADRA2BADRA2CDRD1 | |
| SCHEMBL5708775 | 0.83 | PNMT (0.44) | PNMTADRA2AADRA2BADRA2CHSD17B10 | |
| Hydrochloric Acid SCHEMBL5601615 | 0.80 | PNMT (0.52) | PNMTADRA2AADRA2BADRA2CRECQL | |
| Hydrochloric Acid SCHEMBL5599748 | 0.80 | PNMT (0.52) | PNMTADRA2AADRA2BADRA2CRECQL | |
| Hydrochloric Acid SCHEMBL6101884 | 0.80 | PNMT (0.42) | PNMTADRA2AADRA2BADRA2CHSD17B10 | |
| SCHEMBL20522903 | 0.75 | PNMT (0.55) | PNMTADRA2AADRA2BADRA2CDRD1 | |
| Bromide SCHEMBL30255056 | 0.74 | PNMT (0.53) | PNMTADRA2AADRA2BADRA2CDRD1 | |
| SCHEMBL23683887 | 0.72 | PNMT (0.52) | PNMTADRA2AADRA2BADRA2CDRD1 | |
| SCHEMBL15445351 | 0.72 | PNMT (0.51) | PNMTADRA2AADRA2BADRA2CDRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11680054-B2 | Bronchodilating hetero-linked amides | ARCEDE PHARMA AB (SE) | 2023-06-20 | — | — | US | disclosed |
| US-11680054-B2 | Bronchodilating hetero-linked amides | ARCEDE PHARMA AB (SE) | 2023-06-20 | — | — | US | disclosed |
| EP-3818055-B1 | NOVEL BRONCHODILATING HETERO-LINKED AMIDES | RESPIRATORIUS AB PUBL (SE) | 2022-02-16 | — | — | EP | disclosed |
| US-20210139455-A1 | NOVEL BRONCHODILATING HETERO-LINKED AMIDES | ARCEDE PHARMA AB (SE) | 2021-05-13 | — | — | US | disclosed |
| WO-2020009653-A1 | NOVEL BRONCHODILATING HETERO-LINKED AMIDES | RESPIRATORIUS AB (PUBL) (SE) | 2020-01-09 | — | — | WO | disclosed |
| US-8318768-B2 | Bronchodilating alpha, beta-unsaturated isoquinoline amides | RESPIRATORIUS AB (SE) | 2012-11-27 | — | — | US | disclosed |
| US-8318768-B2 | Bronchodilating alpha, beta-unsaturated isoquinoline amides | RESPIRATORIUS AB (SE) | 2012-11-27 | — | — | US | disclosed |
| US-8318768-B2 | Bronchodilating alpha, beta-unsaturated isoquinoline amides | RESPIRATORIUS AB (SE) | 2012-11-27 | — | — | US | disclosed |
| EP-2181095-B1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2012-08-22 | — | — | EP | disclosed |
| EP-2181095-B1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2012-08-22 | — | — | EP | disclosed |
| US-20100256101-A1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | ARCEDE PHARMA AB (SE) | 2010-10-07 | — | — | US | disclosed |
| US-20100256101-A1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | ARCEDE PHARMA AB (SE) | 2010-10-07 | — | — | US | disclosed |
| US-20100256101-A1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | ARCEDE PHARMA AB (SE) | 2010-10-07 | — | — | US | disclosed |
| EP-2181095-A1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | Respiratorius AB (SE) | 2010-05-05 | — | — | EP | disclosed |
| WO-2009007419-A1 | NOVEL BRONCHODILATING ISOQUINOLINE CARBAMATES | RESPIRATORIUS AB (SE) | 2009-01-15 | — | — | WO | disclosed |
| WO-2009007418-A1 | NOVEL BRONCHODILATING ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2009-01-15 | — | — | WO | disclosed |
| WO-2009007420-A1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2009-01-15 | — | — | WO | disclosed |
| WO-2009007420-A1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2009-01-15 | — | — | WO | disclosed |
| WO-2007011290-A1 | Bronchorelaxing agents based on indol- and isoquinoline derivatives | RESPIRATORIUS AB (SE) | 2007-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11680054-B2 | Bronchodilating hetero-linked amides | PTGIS, PTGIR, ADRB2 | PNMT 1180/4885ADRA2A 30/4885ADRA2B 11/4885 |
| US-20100256101-A1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | PTGIS, ADRB2, ADRB1 | PNMT 2013/4885ADRA2A 13/4885ADRA2B 11/4885 |
| US-20210139455-A1 | NOVEL BRONCHODILATING HETERO-LINKED AMIDES | ADRB2, ADRB1, PTGIS | PNMT 1286/4885ADRA2A 24/4885ADRA2B 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.